Successful Pregnancies with Thiopurine-Allopurinol Co-Therapy for Inflammatory Bowel Disease
نویسندگان
چکیده
منابع مشابه
Successful Pregnancies with Thiopurine-Allopurinol Co-Therapy for Inflammatory Bowel Disease.
BACKGROUND Thiopurines are an effective treatment for moderate to severe inflammatory bowel disease [IBD] and can be used safely in pregnancy. Combining allopurinol with a lower dose of thiopurine can improve clinical efficacy and bypass some adverse reactions associated with thiopurine monotherapy. Data on allopurinol in pregnancy are scarce. We report on a total of 13 cases where thiopurine a...
متن کاملAllopurinol-thiopurine combination therapy in inflammatory bowel disease: are there genetic clues to this puzzle?
Margien L Seinen*,1, Nanne KH de Boer1, Adriaan A van Bodegraven1,2, Stephen B Hanauer3 & Frank Hoentjen4 Department of Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands Department of Internal Medicine, Gastroenterology & Geriatrics, ORBIS Medical Center, The Netherlands Digestive Health Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Infla...
متن کاملOptimizing Thiopurine Therapy in Inflammatory Bowel Disease Among 2 Real-life Intercept Cohorts: Effect of Allopurinol Comedication?
BACKGROUND Thiopurines (azathioprine and mercaptopurine) are frequently used immunosuppressive drugs to maintain remission in patients with inflammatory bowel disease. Half of the conventional thiopurine-derivative users have to discontinue treatment within 5 years, mainly because of intolerable adverse events. Over recent years, different strategies to optimize thiopurine treatment were sugges...
متن کاملThiopurine methyltransferase genotype and thiopurine S-methyltransferase activity in Greek children with inflammatory bowel disease
BACKGROUND Azathioprine (AZA) and 6-mercaptopurine (6MP) are used in the treatment of pediatric inflammatory bowel disease (IBD). Genetic variations in thiopurine S-methyltranfarase (TPMT) gene have been correlated with enzyme activity and with the occurrence of adverse events to AZA and 6MP. The aim of the present study was to examine the sensitivity and specificity of TPMT genotyping for TPMT...
متن کامل6-methylmercaptopurine-induced leukocytopenia during thiopurine therapy in inflammatory bowel disease patients.
BACKGROUND AND AIM Thiopurines have a favorable benefit-risk ratio in the treatment of inflammatory bowel disease. A feared adverse event of thiopurine therapy is myelotoxicity, mostly occurring due to toxic concentrations of the pharmacologically active metabolites 6-thioguaninenucleotides. In oncology, myelosuppression has also been associated with elevated 6-methylmercaptopurine (6-MMP). In ...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2015
ISSN: 1873-9946,1876-4479
DOI: 10.1093/ecco-jcc/jjv072